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[\/et_pb_text][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat||||” text_text_color=”#353740″ text_font_size=”20px” text_line_height=”1.8em” header_font=”||||||||” custom_margin=”||0px||false|false” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”17%” locked=”off” global_colors_info=”{}”]<\/p>\n
We are a pioneering biopharmaceutical company developing novel, effective therapeutics addressing the root cause of Alzheimer\u2019s disease and other neurodegenerative disorders.<\/p>\n
Our breakthrough discovery on the gene regulatory function of the key genetic variants has uncovered the \u201ctrue disease-causing factors\u201d and provided new, unexploited molecular targets for small molecules discovery programs.<\/p>\n
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[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ admin_label=”Skill” _builder_version=”4.16″ custom_padding=”20px||10px|” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat|600|||||||” text_text_color=”#747d88″ text_font_size=”20px” text_line_height=”2em” ul_line_height=”1.6em” custom_margin=”|||” custom_padding=”||2px||false|false” animation_style=”fade” global_colors_info=”{}”]<\/p>\n
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[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat|700|||||||” text_text_color=”#000000″ text_font_size=”20px” text_line_height=”1em” min_height=”40px” custom_margin=”||20px||false|false” custom_padding=”||0px||false|false” animation_style=”flip” animation_intensity_flip=”20%” global_colors_info=”{}”]<\/p>\n
Single nucleotide polymorphism<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat|600|||||||” text_text_color=”#747d88″ text_font_size=”20px” text_line_height=”1em” custom_margin=”||10px||false|false” custom_padding=”||0px||false|false” animation_style=”flip” animation_intensity_flip=”20%” global_colors_info=”{}”]<\/p>\n
Healthy:<\/p>\n
[\/et_pb_text][et_pb_image src=”https:\/\/selonterra.com\/wp-content\/uploads\/2022\/08\/Overview_approach_single_top_healthy.png” title_text=”Overview_approach_single_top_healthy” _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat|600|||||||” text_text_color=”#747d88″ text_font_size=”20px” text_line_height=”1em” custom_margin=”||10px||false|false” custom_padding=”||0px||false|false” animation_style=”flip” animation_intensity_flip=”20%” global_colors_info=”{}”]<\/p>\n
Disease:<\/p>\n
[\/et_pb_text][et_pb_image src=”https:\/\/selonterra.com\/wp-content\/uploads\/2022\/08\/Overview_approach_single_bottom_disease.png” title_text=”Overview_approach_single_bottom_disease” _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat|700|||||||” text_text_color=”#000000″ text_font_size=”20px” text_line_height=”1em” min_height=”40px” custom_margin=”||20px||false|false” custom_padding=”||0px||false|false” animation_style=”flip” animation_intensity_flip=”20%” global_colors_info=”{}”]<\/p>\n
Nucleotide repeat expansion<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat|600|||||||” text_text_color=”#747d88″ text_font_size=”20px” text_line_height=”1em” custom_margin=”||10px||false|false” custom_padding=”||0px||false|false” animation_style=”flip” animation_intensity_flip=”20%” global_colors_info=”{}”]<\/p>\n
Healthy:<\/p>\n
[\/et_pb_text][et_pb_image src=”https:\/\/selonterra.com\/wp-content\/uploads\/2022\/08\/Overview_approach_repeat_top_healthy.png” title_text=”Overview_approach_repeat_top_healthy” _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat|600|||||||” text_text_color=”#747d88″ text_font_size=”20px” text_line_height=”1em” custom_margin=”||10px||false|false” custom_padding=”||0px||false|false” animation_style=”flip” animation_intensity_flip=”20%” global_colors_info=”{}”]<\/p>\n
Disease:<\/p>\n
[\/et_pb_text][et_pb_image src=”https:\/\/selonterra.com\/wp-content\/uploads\/2022\/08\/Overview_approach_repeat_bottom_disease.png” title_text=”Overview_approach_repeat_bottom_disease” _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Selonterra Platform” _builder_version=”4.17.6″ background_color=”#FFFFFF” custom_padding=”60px||60px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row admin_label=”Service Section Title” _builder_version=”4.17.6″ custom_margin=”||0px||false|false” animation_style=”fade” animation_direction=”top” saved_tabs=”all” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Title” _builder_version=”4.16″ text_font=”Montserrat||||||||” text_text_color=”#747d88″ text_font_size=”16px” text_line_height=”1.9em” header_font=”||||||||” header_2_font=”Montserrat|700||on|||||” header_2_font_size=”42px” header_2_line_height=”1.3em” text_orientation=”center” max_width=”700px” module_alignment=”center” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”4%” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_2,1_4″ admin_label=”Service Section Title” _builder_version=”4.17.6″ custom_margin=”||40px|” animation_style=”fade” animation_direction=”top” saved_tabs=”all” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.17.6″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” text_font=”||||||||” text_text_color=”#000000″ header_4_font=”|700||on|||||” background_color=”#f5d34d” custom_padding=”10px|10px|10px|10px|true|true” border_radii=”on|10px|10px|10px|10px” box_shadow_style=”preset3″ global_colors_info=”{}”]<\/p>\n
Development of orally available, disease modifying therapies<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” text_font=”||||||||” text_text_color=”#000000″ header_4_font=”|700||on|||||” background_color=”#f5d34d” custom_padding=”10px|10px|10px|10px|true|true” border_radii=”on|10px|10px|10px|10px” box_shadow_style=”preset3″ global_colors_info=”{}”]<\/p>\n
Small molecule discovery program<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” text_font=”||||||||” text_text_color=”#000000″ header_4_font=”|700||on|||||” background_color=”#f5d34d” custom_padding=”10px|10px|10px|10px|true|true” border_radii=”on|10px|10px|10px|10px” box_shadow_style=”preset3″ global_colors_info=”{}”]<\/p>\n
Identification of molecular route from target to disease<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/selonterra.com\/wp-content\/uploads\/2022\/08\/Overview_platform_circle1.png” title_text=”Overview_platform_circle1″ _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” text_font=”||||||||” text_text_color=”#000000″ header_4_font=”|700||on|||||” background_color=”#f5d34d” custom_padding=”10px|10px|10px|10px|true|true” border_radii=”on|10px|10px|10px|10px” box_shadow_style=”preset3″ global_colors_info=”{}”]<\/p>\n
Strong, compelling genetic links to neurodegenerative diseases<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” text_font=”||||||||” text_text_color=”#000000″ header_4_font=”|700||on|||||” background_color=”#f5d34d” custom_padding=”10px|10px|10px|10px|true|true” border_radii=”on|10px|10px|10px|10px” box_shadow_style=”preset3″ global_colors_info=”{}”]<\/p>\n
Genetic variants control the expression of genes nearby<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” text_font=”||||||||” text_text_color=”#000000″ header_4_font=”|700||on|||||” background_color=”#f5d34d” custom_padding=”10px|10px|10px|10px|true|true” border_radii=”on|10px|10px|10px|10px” box_shadow_style=”preset3″ global_colors_info=”{}”]<\/p>\n
Those genes are the true disease-causing factors<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Pipeline” module_id=”pipeline” _builder_version=”4.17.6″ background_color=”#f7f7f7″ custom_padding=”60px||60px||false|false” da_popup_slug=”pipeline” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row admin_label=”Skill” _builder_version=”4.16″ custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Title” _builder_version=”4.17.6″ text_font=”Montserrat||||||||” text_text_color=”#747d88″ text_font_size=”16px” text_line_height=”1.9em” header_font=”||||||||” header_2_font=”Montserrat|700||on|||||” header_2_font_size=”42px” header_2_line_height=”1.3em” text_orientation=”center” max_width=”700px” module_alignment=”center” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”4%” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat||||” text_text_color=”#747d88″ text_font_size=”16px” text_line_height=”1.8em” text_orientation=”center” width=”90%” module_alignment=”center” custom_margin=”|||” custom_padding=”||20px|” animation_style=”flip” animation_intensity_flip=”20%” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Service Section Title” _builder_version=”4.17.6″ custom_margin=”||0px||false|false” animation_style=”fade” animation_direction=”top” saved_tabs=”all” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][dvmd_table_maker tbl_column_header_count=”2″ tbl_row_header_count=”0″ tbl_tcell_cell_color=”#361A5B” tbl_tcell_cell_align_horz=”center” tbl_tcell_cell_align_vert=”center” tbl_chead_cell_color=”#361A5B” tbl_chead_cell_align_horz=”center” tbl_chead_cell_align_vert=”center” tbl_rhead_cell_color=”#361A5B” _builder_version=”4.17.6″ _module_preset=”default” tbl_tcell_text_text_color=”#FFFFFF” tbl_chead_text_font=”|||on|||||” global_colors_info=”{}”][dvmd_table_maker_item col_label=”Drug Development” col_content=” We have developed small molecule modulators of our novel, unexploited, highly druggable target. Our lead compounds restore APOE4-induced gene expression dysfunction and synaptic deficits. We are poised to rapidly move through lead optimization to IND-enabling studies.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat||||” text_text_color=”#747d88″ text_font_size=”16px” text_line_height=”1.8em” custom_margin=”|||” custom_padding=”||20px|” animation_style=”flip” animation_intensity_flip=”20%” global_colors_info=”{}”]<\/p>\n Important genetic contributors to Parkinson\u2019s disease are variants of the SNCA and LRRK2 genes. We have identified novel drug targets with dysregulated expression levels in human neurons carrying PD associated gene variants.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat||||” text_text_color=”#747d88″ text_font_size=”16px” text_line_height=”1.8em” custom_margin=”|||” custom_padding=”||20px|” animation_style=”flip” animation_intensity_flip=”20%” global_colors_info=”{}”]<\/p>\n We pursue complementary programs for the therapy of ALS caused by nucleotide repeat expansions in C9orf72 and single nucleotide variants in familial AD (APP mutations). Orphan indications offer an additional regulatory protection for a development compound.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Vision and MissionWe are a pioneering biopharmaceutical company developing novel, effective therapeutics addressing the root cause of Alzheimer\u2019s disease and other neurodegenerative disorders. Our breakthrough discovery on the gene regulatory function of the key genetic variants has uncovered the \u201ctrue disease-causing factors\u201d and provided new, unexploited molecular targets for small molecules discovery programs.The Selonterra Value […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-127","page","type-page","status-publish","hentry"],"jetpack-related-posts":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/selonterra.com\/index.php\/wp-json\/wp\/v2\/pages\/127","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/selonterra.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/selonterra.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/selonterra.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/selonterra.com\/index.php\/wp-json\/wp\/v2\/comments?post=127"}],"version-history":[{"count":9,"href":"https:\/\/selonterra.com\/index.php\/wp-json\/wp\/v2\/pages\/127\/revisions"}],"predecessor-version":[{"id":473,"href":"https:\/\/selonterra.com\/index.php\/wp-json\/wp\/v2\/pages\/127\/revisions\/473"}],"wp:attachment":[{"href":"https:\/\/selonterra.com\/index.php\/wp-json\/wp\/v2\/media?parent=127"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nDiscovery” _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][\/dvmd_table_maker_item][dvmd_table_maker_item col_label=”Drug Development 2″ col_content=”
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In Vivo POC” _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][\/dvmd_table_maker_item][dvmd_table_maker_item col_content=”
\nIND-Enabling” _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][\/dvmd_table_maker_item][dvmd_table_maker_item col_content=”
\nPhase 1 with POC” _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][\/dvmd_table_maker_item][\/dvmd_table_maker][et_pb_counters bar_bg_color=”#fcd21d” use_percentages=”off” _builder_version=”4.17.6″ title_font=”Montserrat|700||on|||||” title_text_color=”#353740″ title_font_size=”14px” title_letter_spacing=”1px” title_line_height=”2em” percent_font_size=”1px” custom_padding=”|||” animation_style=”fold” animation_direction=”left” animation_intensity_fold=”30%” global_colors_info=”{}”][et_pb_counter percent=”58″ _builder_version=”4.17.6″ title_font=”|700|||||||” title_font_size=”14px” percent_font=”||||” background_color=”#ececee” custom_margin=”||20px||false|false” custom_padding=”|||” global_colors_info=”{}” bar_background_color_default=”#fcd21d” use_percentages=”off”]Alzheimer’s Disease (APOE4)[\/et_pb_counter][et_pb_counter percent=”48″ _builder_version=”4.17.6″ _module_preset=”default” background_color=”#ececee” background_enable_color=”on” custom_margin=”||20px||false|false” global_colors_info=”{}” bar_background_color_default=”#fcd21d” use_percentages=”off”]Parkinson’s Disease (SNCA A53T, LRRK2 G2019S)[\/et_pb_counter][et_pb_counter percent=”48″ _builder_version=”4.17.6″ title_font=”||||||||” percent_font=”||||” background_color=”#ececee” custom_margin=”||20px||false|false” custom_padding=”|||” global_colors_info=”{}” bar_background_color_default=”#fcd21d” use_percentages=”off”]ALS \/ FTD (C9orf72 Repeat Expansion)[\/et_pb_counter][et_pb_counter percent=”38″ _builder_version=”4.17.6″ title_font=”||||||||” percent_font=”||||” background_color=”#ececee” custom_margin=”||20px||false|false” custom_padding=”|||” global_colors_info=”{}” bar_background_color_default=”#fcd21d” use_percentages=”off”]Alzheimer’s Disease (Familial mutations)[\/et_pb_counter][\/et_pb_counters][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ admin_label=”Skill” _builder_version=”4.16″ custom_padding=”20px||10px|” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.6″ text_font=”Montserrat||||” text_text_color=”#747d88″ text_font_size=”16px” text_line_height=”1.8em” custom_margin=”|||” custom_padding=”||20px|” animation_style=”flip” animation_intensity_flip=”20%” global_colors_info=”{}”]<\/p>\nAlzheimer’s disease<\/strong><\/h1>\n
Parkinson’s disease<\/strong><\/h1>\n
Extended indications<\/strong><\/h1>\n